Targeting the interaction between Rad51 and BRCA2 using fragment-based methods

Targeting the interaction between Rad51 and BRCA2 using fragment-based methods

This is the crystal structure by Dr Luca Pellegrini and co-workers of a complex between human recombinase Rad51 with the fourth BRC repeat from breast cancer associated protein BRCA2. We are applying fragment based drug discovery methods to target this protein-protein interaction with aim to develop small molecule inhibtors that can be used both as chemical tools for research and as lead compounds for eventual drug development.

PDB:
1n0w
Reference
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. (2002) Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, Venkitaraman AR. Nature 420:287-293