Natural variant in 'Warrior Gene' amine oxidase A

Natural variant in 'Warrior Gene' amine oxidase A

In [1]: from credopymol import *
In [2]: s = StructureAdaptor().fetchByPDB('2Z5X')
In [3]: s.load()
 
In [4]: xref = s.getMutations()[0]
 
In [5]: xref
Out[5]: <XRef(Residue,dbSNP,rs1803986)>
 
In [6]: xref.description 
Out[6]: 'M/I NON_SYNONYMOUS_CODING'
 
In [7]: mut_res = xref.getObject()
 
In [8]: mut_res
Out[8]: <Residue(445, MET, )>
 
In [9]: mut_res.show()
 
In [10]: s.Ligands[3] 
Out[10]: Ligand(600, FAD, A)
 
In [11]: s.Ligands[3].showContacts()

A natural variant in amine oxidase A is highlighted in PDB structure 2Z5X. The affected methionine residue, in contact with the cofactor FAD, is shown as sticks in magenta. Amine Oxidase A degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the outer mitochondrial membrane. The gene is adjacent to a related gene (MAOB) on the opposite strand of chromosome X. Mutation in this gene results in monoamine oxidase deficiency, or Brunner syndrome. The enzyme is also called 'warrior gene' because individuals with different versions of this gene display higher levels of aggression in response to provocation.