Publications by Tom L. Blundell before 1997

S. D. Rufino, L. E. Donate, L. Canard, and T. L. Blundell.: Analysis, clustering and prediction of the conformation of short and medium size loops connecting regular secondary structures .
Pac Symp Biocomput, 10(9):570-589, 1996.
Medline link.
T. L. Blundell and N. Srinivasan.: Symmetry, stability, and dynamics of multidomain and multicomponent protein systems .
Proc. Nat. Acad. Sci. USA, 93(25):14243-14248, Dec 1996.
Medline link.
L. E. Donate, S. D. Rufino, L. H. Canard, and T. L. Blundell.: Conformational analysis and clustering of short and medium size loops connecting regular secondary structures: a database for modeling and prediction .
Protein Sci., 5(12):2600-2616, Dec 1996.
Medline link.
T. L. Blundell.: Structure-based drug design .
Nature, 384(6604 Suppl):23-26, Nov 1996.
Medline link.
P. G. Nugent, A. Albert, P. Orprayoon, J. Wilsher, J. E. Pitts, T. L. Blundell, and V. Dhanaraj.: Protein engineering loops in aspartic proteinases: site- directed mutagenesis, biochemical characterization and X-ray analysis of chymosin with a replaced loop from rhizopuspepsin .
Prot. Engng, 9(10):885-893, Oct 1996.
Medline link.
K. Guruprasad, T. L. Blundell, S. Xie, J. Green, B. Szafranska, R. J. Nagel, K. McDowell, C. B. Baker, and R. M. Roberts.: Comparative modelling and analysis of amino acid substitutions suggests that the family of pregnancy- associated glycoproteins includes both active and inactive aspartic proteinases .
Prot. Engng, 9(10):849-856, Oct 1996.
Medline link.
N. Srinivasan, B. Bax, T. L. Blundell, and P. J. Parker.: Structural aspects of the functional modules in human protein kinase-C deduced from comparative analyses .
Proteins: Struct. Funct. Genet., 26(2):217-235, Oct 1996.
Medline link.
Z. Y. Zhu and T. L. Blundell.: The use of amino acid patterns of classified helices and strands in secondary structure prediction .
J. Mol. Biol., 260(2):261-276, Jul 1996.
Medline link.
E. N. Baker, T. L. Blundell, M. Vijayan, E. Dodson, G. Dodson, G. L. Gilliland, and J. L. Sussman.: Archival journal requirements for data deposition [letter] .
Biophys. J., 70(6):2994, Jun 1996.
Medline link.
G. V. Louie, P. D. Brownlie, R. Lambert, J. B. Cooper, T. L. Blundell, S. P. Wood, V. N. Malashkevich, A. Hadener, M. J. Warren, and P. M. Shoolingin-Jordan.: The three-dimensional structure of Escherichia coli porphobilinogen deaminase at 1.76-Å resolution .
Proteins: Struct. Funct. Genet., 25(1):48-78, May 1996.
Medline link.
V. Dhanaraj, Q. Z. Ye, L. L. Johnson, D. J. Hupe, D. F. Ortwine, J. B. Dunbar, Jr, J. R. Rubin, A. Pavlovsky, C. Humblet, and T. L. Blundell.: X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily .
Structure, 4(4):375-386, Apr 1996.
Medline link Article on-line.
V. Dhanaraj, Q. Z. Ye, L. L. Johnson, D. J. Hupe, D. F. Ortwine, J. B. Dunbar, Jr, J. R. Rubin, A. Pavlovsky, C. Humblet, and T. L. Blundell.: Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures .
Drug Des Discov, 13(3-4):3-14, Apr 1996.
Medline link.
V. Srinivasan, M. D. Waterfield, and T. L. Blundell.: Comparative analysis of the regions binding -subunits in Galpha and PH domains .
Biochem. Biophys. Res. Comm., 220(3):697-702, Mar 1996.
Medline link.
M. Introna, V. V. Alles, M. Castellano, G. Picardi, L. De Gioia, B. Bottazzai, G. Peri, F. Breviario, M. Salmona, L. De Gregorio, T. A. Dragani, N. Srinivasan, T. L. Blundell, T. A. Hamilton, and A. Mantovani.: Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites .
Blood, 87(5):1862-1872, Mar 1996.
Medline link.
E. N. Baker, T. L. Blundell, M. Vijayan, E. Dodson, G. Dodson, G. L. Gilliland, and J. L. Sussman.: International Seminar-cum-School on Macromolecular Crystallographic Data at Calcutta, India [letter] .
Anticancer Drug Des, 11(2):173-174, Mar 1996.
Medline link.
E. N. Baker, T. L. Blundell, M. Vijayan, E. Dodson, G. Dodson, G. L. Gilliland, and J. L. Sussman.: LETTER TO THE EDITOR .
Biochem. Biophys. Res. Comm., 219(3):976-977, Feb 1996.
Medline link.
E. N. Baker, T. L. Blundell, M. Vijayan, E. Dodson, G. Dodson, G. L. Gilliland, and J. L. Sussman.: A formal discussion of the archival journal requirements for data deposition [letter] .
Biochem. Biophys. Res. Comm., 219(3):976-977, Feb 1996.
Medline link.
E. N. Baker, T. L. Blundell, E. Dodson, G. Dodson, G. L. Gilliland, J. L. Sussman, and M. Vijayan.: Diffraction data deposition .
Structure, 4(2):217, Feb 1996.
Medline link Article on-line.
E. N. Baker, T. L. Blundell, M. Vijayan, E. Dodson, G. Dodson, G. L. Gilliland, and J. L. Sussman.: Archival journal requirements of macromolecular crystallographic data [letter] .
J Biomol Struct Dyn, 13(4):583, Feb 1996.
Medline link.
E. N. Baker, T. L. Blundell, M. Vijayan, E. Dodson, G. Dodson, G. I. Gilliland, and J. L. Sussman.: Crystallographic data deposition [letter] .
Nature, 379(6562):202, Jan 1996.
Medline link.
R. Sowdhamini, S. D. Rufino, and T. L. Blundell.: A database of globular protein structural domains: clustering of representative family members into similar folds .
Structure, 1(3):209-220, 1996.
Medline link Article on-line.
T. L. Blundell.: The Leon Golberg Memorial Lecture. Structural molecular biology and drug discovery .
Food Chem Toxicol, 33(11):979-985, Nov 1995.
Medline link.
T. L. Blundell and Z. Y. Zhu.: The -helix as seen from the protein tertiary structure: a 3-D structural classification .
Biophys Chem, 55(1-2):167-184, JunJul 1995.
Medline link.
C. Rao-Naik, K. Guruprasad, B. Batley, S. Rapundalo, J. Hill, T. Blundell, J. Kay, and B. M. Dunn.: Exploring the binding preferences/specificity in the active site of human cathepsin E .
Proteins: Struct. Funct. Genet., 22(2):168-181, Jun 1995.
Medline link.
L. Guruprasad, V. Dhanaraj, D. Timm, T. L. Blundell, I. Gout, and M. D. Waterfield.: The crystal structure of the N-terminal SH3 domain of Grb2 .
J. Mol. Biol., 248(4):856-866, May 1995.
Medline link.
R. Sowdhamini and T. L. Blundell.: An automatic method involving cluster analysis of secondary structures for the identification of domains in proteins .
Protein Sci., 4(3):506-520, Mar 1995.
Medline link.
N. Q. McDonald, J. Murray-Rust, and T. L. Blundell.: The first structure of a receptor tyrosine kinase domain: a further step in understanding the molecular basis of insulin action .
Structure, 3(1):1-6, Jan 1995.
Medline link.
R. R. Dhanaraj, J. E. Pitts, P. Nugent, P. Orprayoon, J. B. Cooper, T. L. Blundell, J. Uusitalo, and M. Penttila.: Protein engineering of surface loops: preliminary X-ray analysis of the CHY155-165RHI mutant .
Adv Exp Med Biol, 362(1):95-99, 1995.
Medline link.
J. Kervinen, K. Tormakangas, P. Runeberg-Roos, K. Guruprasad, T. Blundell, and T. H. Teeri.: Structure and possible function of aspartic proteinases in barley and other plants .
Adv Exp Med Biol, 362(1):241-254, 1995.
Medline link.
C. F. Aguilar, V. Dhanaraj, K. Guruprasad, C. Dealwis, M. Badasso, J. B. Cooper, S. P. Wood, and T. L. Blundell.: Comparisons of the three-dimensional structures, specificities and glycosylation of renins, yeast proteinase A and cathepsin D .
Adv Exp Med Biol, 362(1):155-166, 1995.
Medline link.
L. Narasimhan, J. Singh, C. Humblet, K. Guruprasad, and T. Blundell.: Snail and spider toxins share a similar tertiary structure and 'cystine motif' [letter] .
Nat. Struct. Biol., 1(12):850-852, Dec 1994.
Medline link.
L. E. Donate, E. Gherardi, N. Srinivasan, R. Sowdhamini, S. Aparicio, and T. L. Blundell.: Molecular evolution and domain structure of plasminogen- related growth factors (HGF/SF and HGF1/MSP) .
Protein Sci., 3(12):2378-2394, Dec 1994.
Medline link.
N. Srinivasan, H. E. White, J. Emsley, S. P. Wood, M. B. Pepys, and T. L. Blundell.: Comparative analyses of pentraxins: implications for protomer assembly and ligand binding .
Structure, 2(11):1017-1027, Nov 1994.
Medline link.
R. A. Bradshaw, J. Murray-Rust, C. F. Ibanez, N. Q. McDonald, R. Lapatto, and T. L. Blundell.: Nerve growth factor: structure/function relationships .
Protein Sci., 3(11):1901-1913, Nov 1994.
Medline link.
D. Timm, K. Salim, I. Gout, L. Guruprasad, M. Waterfield, and T. Blundell.: Crystal structure of the pleckstrin homology domain from dynamin .
Nat. Struct. Biol., 1(11):782-788, Nov 1994.
Medline link, PDB:2DYN.
P. D. Brownlie, R. Lambert, G. V. Louie, P. M. Jordan, T. L. Blundell, M. J. Warren, J. B. Cooper, and S. P. Wood.: The three-dimensional structures of mutants of porphobilinogen deaminase: toward an understanding of the structural basis of acute intermittent porphyria .
Protein Sci., 3(10):1644-1650, Oct 1994.
Medline link.
K. Guruprasad, K. Tormakangas, J. Kervinen, and T. L. Blundell.: Comparative modelling of barley-grain aspartic proteinase: a structural rationale for observed hydrolytic specificity .
FEBS Lett., 352(2):131-136, Sep 1994.
Medline link.
A. C. May and T. L. Blundell.: Automated comparative modelling of protein structures .
Curr. Opin. Biotech., 5(4):355-360, Aug 1994.
Medline link.
A. C. May, M. S. Johnson, S. D. Rufino, H. Wako, Z. Y. Zhu, R. Sowdhamini, N. Srinivasan, M. A. Rodionov, and T. L. Blundell.: The recognition of protein structure and function from sequence: adding value to genome data .
Philos Trans R Soc Lond B Biol Sci, 344(1310):373-381, Jun 1994.
Medline link.
H. Wako and T. L. Blundell.: Use of amino acid environment-dependent substitution tables and conformational propensities in structure prediction from aligned sequences of homologous proteins. II. Secondary structures .
J. Mol. Biol., 238(5):693-708, May 1994.
Medline link.
H. Wako and T. L. Blundell.: Use of amino acid environment-dependent substitution tables and conformational propensities in structure prediction from aligned sequences of homologous proteins. I. Solvent accessibility classes .
J. Mol. Biol., 238(5):682-692, May 1994.
Medline link.
D. Donnelly, J. P. Overington, and T. L. Blundell.: The prediction and orientation of -helices from sequence alignments: the combined use of environment- dependent substitution tables, Fourier transform methods and helix capping rules .
Prot. Engng, 7(5):645-653, May 1994.
Medline link.
T. L. Blundell.: Problems and solutions in protein engineering-towards rational design [editorial] .
Trends Biotech., 12(5):145-148, May 1994.
Medline link.
R. H. Newman, E. Carpenter, P. S. Freemont, T. L. Blundell, and P. J. Parker.: Microcrystals of the 1 isoenzyme of protein kinase C: an electron microscopic study .
Biochem. J., 298 ( Pt 2)(5):391-393, Mar 1994.
Medline link.
C. G. Dealwis, C. Frazao, M. Badasso, J. B. Cooper, I. J. Tickle, H. Driessen, T. L. Blundell, K. Murakami, H. Miyazaki, J. Sueiras-Diaz, and a. l. et.: X-ray analysis at 2.0 Å resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen .
J. Mol. Biol., 236(1):342-360, Feb 1994.
Medline link.
S. D. Rufino and T. L. Blundell.: Structure-based identification and clustering of protein families and superfamilies .
J Comput Aided Mol Des, 8(1):5-27, Feb 1994.
Medline link.
T. L. Blundell.: Metalloproteinase superfamilies and drug design [news] .
Nat. Struct. Biol., 1(2):73-75, Feb 1994.
Medline link.
J. Emsley, H. E. White, B. P. O'Hara, G. Oliva, N. Srinivasan, I. J. Tickle, T. L. Blundell, M. B. Pepys, and S. P. Wood.: Structure of pentameric human serum amyloid P component .
Nature, 367(6461):338-345, Jan 1994.
Medline link.
M. S. Johnson, N. Srinivasan, R. Sowdhamini, and T. L. Blundell.: Knowledge-based protein modeling .
Crit Rev Biochem Mol Biol, 29(1):1-68, 1994.
Medline link.
D. Donnelly, J. B. Findlay, and T. L. Blundell.: The evolution and structure of aminergic G protein-coupled receptors .
Receptors Channels, 2(1):61-78, 1994.
Medline link.
P. J. Whittle and T. L. Blundell.: Protein structure-based drug design .
Annu. Rev. Biophys. Biomol. Struct., 23(1):349-375, 1994.
Medline link.
R. Lambert, P. D. Brownlie, S. C. Woodcock, G. V. Louie, J. C. Cooper, M. J. Warren, P. M. Jordan, T. L. Blundell, and S. P. Wood.: Structural studies on porphobilinogen deaminase .
Ciba Found Symp, 180(1):97-104 105, 1994.
Medline link.
A. Sali and T. L. Blundell.: Comparative protein modelling by satisfaction of spatial restraints .
J. Mol. Biol., 234(3):779-815, Dec 1993.
Medline link.
J. Murray-Rust, N. Q. McDonald, T. L. Blundell, M. Hosang, C. Oefner, F. Winkler, and R. A. Bradshaw.: Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors .
Structure, 1(2):153-159, Oct 1993.
Medline link.
B. V. Reddy and T. L. Blundell.: Packing of secondary structural elements in proteins. Analysis and prediction of inter-helix distances .
J. Mol. Biol., 233(3):464-479, Oct 1993.
Medline link.
J. P. Overington, Z. Y. Zhu, A. Sali, M. S. Johnson, R. Sowdhamini, G. V. Louie, and T. L. Blundell.: Molecular recognition in protein families: a database of aligned three-dimensional structures of related proteins .
Biochem. Soc. Trans., 21 ( Pt 3)(3):597-604, Aug 1993.
Medline link.
M. Badasso, S. P. Wood, C. Aguilar, J. B. Cooper, T. L. Blundell, and T. Dreyer.: Crystallization and preliminary crystallographic characterization of aspartic proteinase-A from baker's yeast and its complexes with inhibitors .
J. Mol. Biol., 232(2):701-703, Jul 1993.
Medline link.
N. Srinivasan and T. L. Blundell.: An evaluation of the performance of an automated procedure for comparative modelling of protein tertiary structure .
Prot. Engng, 6(5):501-512, Jul 1993.
Medline link.
M. S. Johnson, J. P. Overington, and T. L. Blundell.: Alignment and searching for common protein folds using a data bank of structural templates .
J. Mol. Biol., 231(3):735-752, Jun 1993.
Medline link.
T. L. Blundell and M. S. Johnson.: Catching a common fold .
Protein Sci., 2(6):877-883, Jun 1993.
Medline link.
M. Newman, F. Watson, P. Roychowdhury, H. Jones, M. Badasso, A. Cleasby, S. P. Wood, I. J. Tickle, and T. L. Blundell.: X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0 Å resolution of the aspartic proteinase from Mucor pusillus .
J. Mol. Biol., 230(1):260-283, Mar 1993.
Medline link.
C. F. Aguilar, M. P. Newman, J. Sanz Aparicio, J. B. Cooper, I. J. Tickle, and T. L. Blundell.: The use of protein homologues in the rotation function .
Acta Crystallogr. A, 49 ( Pt 2)(1):306-315, Mar 1993.
Medline link.
R. A. Bradshaw, T. L. Blundell, R. Lapatto, N. Q. McDonald, and J. Murray-Rust.: Nerve growth factor revisited .
Trends Biochem. Sci., 18(2):48-52, Feb 1993.
Medline link.
P. E. Scarborough, K. Guruprasad, C. Topham, G. R. Richo, G. E. Conner, T. L. Blundell, and B. M. Dunn.: Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling .
Protein Sci., 2(2):264-276, Feb 1993.
Medline link.
A. M. Hoffren, M. Saloheimo, P. Thomas, J. P. Overington, M. S. Johnson, J. K. Knowles, and T. L. Blundell.: Modelling of the lignin peroxidase LIII of Phlebia radiata: use of a sequence template generated from a 3-D structure .
Prot. Engng, 6(2):177-182, Feb 1993.
Medline link.
D. Bailey, J. B. Cooper, B. Veerapandian, T. L. Blundell, B. Atrash, D. M. Jones, and M. Szelke.: X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin .
Biochem. J., 289 ( Pt 2)(2):363-371, Jan 1993.
Medline link.
C. M. Topham, A. McLeod, F. Eisenmenger, J. P. Overington, M. S. Johnson, and T. L. Blundell.: Fragment ranking in modelling of protein structure. Conformationally constrained environmental amino acid substitution tables .
J. Mol. Biol., 229(1):194-220, Jan 1993.
Medline link.
D. Donnelly, J. P. Overington, S. V. Ruffle, J. H. Nugent, and T. L. Blundell.: Modeling -helical transmembrane domains: the calculation and use of substitution tables for lipid-facing residues .
Protein Sci., 2(1):55-70, Jan 1993.
Medline link.
T. Blundell, R. Hubbard, and M. A. Weiss.: Structural biology and diabetes mellitus: molecular pathogenesis and rational drug design .
Diabetologia, 35 Suppl 2(1):S69-S76, Dec 1992.
Medline link.
G. Panayotou, B. Bax, I. Gout, M. Federwisch, B. Wroblowski, R. Dhand, M. J. Fry, T. L. Blundell, A. Wollmer, and M. D. Waterfield.: Interaction of the p85 subunit of PI 3-kinase and its N- terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes .
EMBO J., 11(12):4261-4272, Dec 1992.
Medline link.
J. Cooper, W. Quail, C. Frazao, S. I. Foundling, T. L. Blundell, C. Humblet, E. A. Lunney, W. T. Lowther, and B. M. Dunn.: X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors .
Biochemistry, 31(35):8142-8150, Sep 1992.
Medline link.
G. V. Louie, P. D. Brownlie, R. Lambert, J. B. Cooper, T. L. Blundell, S. P. Wood, M. J. Warren, S. C. Woodcock, and P. M. Jordan.: Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site .
Nature, 359(6390):33-39, Sep 1992.
Medline link.
J. Murray-Rust, A. N. McLeod, T. L. Blundell, and S. P. Wood.: Structure and evolution of insulins: implications for receptor binding .
BioEssays, 14(5):325-331, May 1992.
Medline link.
C. F. Ibanez, T. Ebendal, G. Barbany, J. Murray-Rust, T. L. Blundell, and H. Persson.: Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product .
J. Cell Sci., 69(2):329-341, Apr 1992.
Medline link.
P. M. Jordan, M. J. Warren, B. I. Mgbeje, S. P. Wood, J. B. Cooper, G. Louie, P. Brownlie, R. Lambert, and T. L. Blundell.: Crystallization and preliminary X-ray investigation of Escherichia coli porphobilinogen deaminase .
J. Mol. Biol., 224(1):269-271, Mar 1992.
Medline link.
B. Veerapandian, J. B. Cooper, A. Sali, T. L. Blundell, R. L. Rosati, B. W. Dominy, D. B. Damon, and D. J. Hoover.: Direct observation by X-ray analysis of the tetrahedral "intermediate" of aspartic proteinases .
Protein Sci., 1(3):322-328, Mar 1992.
Medline link.
A. Sali, B. Veerapandian, J. B. Cooper, D. S. Moss, T. Hofmann, and T. L. Blundell.: Domain flexibility in aspartic proteinases .
Proteins: Struct. Funct. Genet., 12(2):158-170, Feb 1992.
Medline link.
J. Overington, D. Donnelly, M. S. Johnson, A. Sali, and T. L. Blundell.: Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds .
Protein Sci., 1(2):216-226, Feb 1992.
Medline link.
M. Badasso, C. Frazao, B. L. Sibanda, V. Dhanaraj, C. DeAlwis, J. B. Cooper, S. P. Wood, T. L. Blundell, K. Murakami, H. Miyazaki, and a. l. et.: Crystallization and preliminary X-ray analysis of complexes of peptide inhibitors with human recombinant and mouse submandibular renins .
J. Mol. Biol., 223(2):447-453, Jan 1992.
Medline link.
Z. Y. Zhu, A. Sali, and T. L. Blundell.: A variable gap penalty function and feature weights for protein 3-D structure comparisons .
Prot. Engng, 5(1):43-51, Jan 1992.
Medline link.
J. E. Pitts, V. Dhanaraj, C. G. Dealwis, D. Mantafounis, P. Nugent, P. Orprayoon, J. B. Cooper, M. Newman, and T. L. Blundell.: Multidisciplinary cycles for protein engineering: site- directed mutagenesis and X-ray structural studies of aspartic proteinases .
Scand J Clin Lab Invest Suppl, 210(1):39-50, 1992.
Medline link.
R. Lapatto, V. Nalini, B. Bax, H. Driessen, P. F. Lindley, T. L. Blundell, and C. Slingsby.: High resolution structure of an oligomeric eye lens - crystallin. Loops, arches, linkers and interfaces in B2 dimer compared to a monomeric -crystallin .
J. Mol. Biol., 222(4):1067-1083, Dec 1991.
Medline link.
N. Q. McDonald, R. Lapatto, J. Murray-Rust, J. Gunning, A. Wlodawer, and T. L. Blundell.: New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor .
Nature, 354(6352):411-414, Dec 1991.
Medline link.
M. Newman, M. Safro, C. Frazao, G. Khan, A. Zdanov, I. J. Tickle, T. L. Blundell, and N. Andreeva.: X-ray analyses of aspartic proteinases. IV. Structure and refinement at 2.2 Å resolution of bovine chymosin .
J. Mol. Biol., 221(4):1295-1309, Oct 1991.
Medline link.
P. Orprayoon, J. E. Pitts, P. Nugent, D. Mantafounis, S. E. Lawler, T. L. Blundell, J. Uusitalo, and M. Penttila.: Protein engineering of the surface loops of chymosin .
Biochem. Soc. Trans., 19(3):265S, Aug 1991.
Medline link.
N. Q. McDonald and T. L. Blundell.: Crystallization and characterization of the high molecular weight form of nerve growth factor (7 S NGF) .
J. Mol. Biol., 219(4):595-601, Jun 1991.
Medline link.
T. L. Blundell.: Comparative analysis of protein three-dimensional structures and an approach to the inverse folding problem .
Ciba Found Symp, 161(4):28-36 37, 1991.
Medline link.
T. L. Blundell, J. B. Cooper, A. Sali, and Z. Y. Zhu.: Comparisons of the sequences, 3-D structures and mechanisms of pepsin-like and retroviral aspartic proteinases .
Adv Exp Med Biol, 306(4):443-453, 1991.
Medline link.
E. A. Lunney, C. C. Humblet, J. T. Repine, T. L. Blundell, J. B. Cooper, and B. L. Sibanda.: Molecular modeling of renin inhibitor P2 substituents .
Adv Exp Med Biol, 306(4):391-394, 1991.
Medline link.
D. J. Hoover, B. Veerapandian, J. B. Cooper, D. B. Damon, B. W. Dominy, R. L. Rosati, and T. L. Blundell.: X-ray analysis of a difluorostatone renin inhibitor bound as the tetrahedral hydrate to the aspartic protease endothiapepsin .
Adv Exp Med Biol, 306(4):269-273, 1991.
Medline link.
B. Veerapandian, J. B. Cooper, A. Sali, and T. L. Blundell.: X-ray analyses of aspartic proteinases. III Three- dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 Å resolution .
J. Mol. Biol., 216(4):1017-1029, Dec 1990.
Medline link, PDB:2ER7.
T. L. Blundell, R. Lapatto, A. F. Wilderspin, A. M. Hemmings, P. M. Hobart, D. E. Danley, and P. J. Whittle.: The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS .
Trends Biochem. Sci., 15(11):425-430, Nov 1990.
Medline link.
B. Bax, R. Lapatto, V. Nalini, H. Driessen, P. F. Lindley, D. Mahadevan, T. L. Blundell, and C. Slingsby.: X-ray analysis of B2-crystallin and evolution of oligomeric lens proteins .
Nature, 347(6295):776-780, Oct 1990.
Medline link.
J. Overington, M. S. Johnson, A. Sali, and T. L. Blundell.: Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction .
Proc R Soc Lond B Biol Sci, 241(1301):132-145, Aug 1990.
Medline link.
J. B. Cooper, G. Khan, G. Taylor, I. J. Tickle, and T. L. Blundell.: X-ray analyses of aspartic proteinases. II. Three- dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 Å resolution .
J. Mol. Biol., 214(1):199-222, Jul 1990.
Medline link.
A. Sali, J. P. Overington, M. S. Johnson, and T. L. Blundell.: From comparisons of protein sequences and structures to protein modelling and design .
Trends Biochem. Sci., 15(6):235-240, Jun 1990.
Medline link.
J. Husain, T. L. Blundell, S. Cooper, J. E. Pitts, I. J. Tickle, S. P. Wood, V. J. Hruby, A. Buku, A. J. Fischman, H. R. Wyssbrod, and a. l. et.: The conformation of deamino-oxytocin: X-ray analysis of the 'dry' and 'wet' forms [published erratum appears in Philos Trans R Soc Lond Biol 1990 Jun 30;328(1251):239] .
Philos Trans R Soc Lond B Biol Sci, 327(1243):625-654, Apr 1990.
Medline link.
A. Sali and T. L. Blundell.: Definition of general topological equivalence in protein structures. A procedure involving comparison of properties and relationships through simulated annealing and dynamic programming .
J. Mol. Biol., 212(2):403-428, Mar 1990.
Medline link.
T. L. Blundell, J. A. Jenkins, B. T. Sewell, L. H. Pearl, J. B. Cooper, I. J. Tickle, B. Veerapandian, and S. P. Wood.: X-ray analyses of aspartic proteinases. The three- dimensional structure at 2.1 Å resolution of endothiapepsin .
J. Mol. Biol., 211(4):919-941, Feb 1990.
Medline link.
M. S. Johnson, A. Sali, and T. L. Blundell.: Phylogenetic relationships from three-dimensional protein structures .
Methods Enzymol., 183(4):670-690, 1990.
Medline link.
M. D. Waterfield, C. Greenfield, I. Hiles, M. Federwisch, A. Wollmer, T. L. Blundell, and N. McDonald.: The use of optical techniques to detect conformational changes associated with the interaction of epidermal growth factor and its receptor .
Adv Second Messenger Phosphoprotein Res, 24(4):301-306, 1990.
Medline link.
M. S. Johnson, M. J. Sutcliffe, and T. L. Blundell.: Molecular anatomy: phyletic relationships derived from three-dimensional structures of proteins .
J. Mol. Evol., 30(1):43-59, Jan 1990.
Medline link.
C. M. Topham, P. Thomas, J. P. Overington, M. S. Johnson, F. Eisenmenger, and T. L. Blundell.: An assessment of COMPOSER: a rule-based approach to modelling protein structure .
Biochem Soc Symp, 57(1):1-9, 1990.
Medline link.
N. Q. McDonald, R. Lapatto, J. Murray-Rust, and T. L. Blundell.: X-ray crystallographic studies on murine nerve growth factor .
J Cell Sci Suppl, 13(1):19-30, 1990.
Medline link.
C. Greenfield, I. Hiles, M. D. Waterfield, M. Federwisch, A. Wollmer, T. L. Blundell, and N. McDonald.: Epidermal growth factor binding induces a conformational change in the external domain of its receptor .
EMBO J., 8(13):4115-4123, Dec 1989.
Medline link.
R. Lapatto, T. Blundell, A. Hemmings, J. Overington, A. Wilderspin, S. Wood, J. R. Merson, P. J. Whittle, D. E. Danley, K. F. Geoghegan, and a. l. et.: X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes .
Nature, 342(6247):299-302, Nov 1989.
Medline link.
J. B. Cooper, S. I. Foundling, T. L. Blundell, J. Boger, R. A. Jupp, and J. Kay.: X-ray studies of aspartic proteinase-statine inhibitor complexes .
Biochemistry, 28(21):8596-8603, Oct 1989.
Medline link, PDB:2ER9.
T. L. Blundell, G. Elliott, S. P. Gardner, T. Hubbard, S. Islam, M. Johnson, D. Mantafounis, P. Murray-Rust, J. Overington, J. E. Pitts, and a. l. et.: Protein engineering and design .
Philos Trans R Soc Lond B Biol Sci, 324(1224):447-460, Aug 1989.
Medline link.
A. Sali, B. Veerapandian, J. B. Cooper, S. I. Foundling, D. J. Hoover, and T. L. Blundell.: High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme .
EMBO J., 8(8):2179-2188, Aug 1989.
Medline link.
D. Donnelly, M. S. Johnson, T. L. Blundell, and J. Saunders.: An analysis of the periodicity of conserved residues in sequence alignments of G-protein coupled receptors. Implications for the three-dimensional structure .
FEBS Lett., 251(1-2):109-116, Jul 1989.
Medline link.
B. L. Sibanda, T. L. Blundell, and J. M. Thornton.: Conformation of -hairpins in protein structures. A systematic classification with applications to modelling by homology, electron density fitting and protein engineering .
J. Mol. Biol., 206(4):759-777, Apr 1989.
Medline link.
N. McDonald, J. Murray-Rust, and T. Blundell.: Structure-function relationships of growth factors and their receptors .
Br Med Bull, 45(2):554-569, Apr 1989.
Medline link.
T. Blundell and L. Pearl.: Retroviral proteinases. A second front against AIDS [news] .
Nature, 337(6208):596-597, Feb 1989.
Medline link.
J. M. Thornton, J. Singh, S. Campbell, and T. L. Blundell.: Protein-protein recognition via side-chain interactions .
Biochem. Soc. Trans., 16(6):927-930, Dec 1988.
Medline link.
M. Baudys, S. Foundling, M. Pavlik, T. Blundell, and V. Kostka.: Protein chemical characterization of Mucor pusillus aspartic proteinase. Amino acid sequence homology with the other aspartic proteinases, disulfide bond arrangement and site of carbohydrate attachment .
FEBS Lett., 235(1-2):271-274, Aug 1988.
Medline link.
E. N. Baker, T. L. Blundell, J. F. Cutfield, S. M. Cutfield, E. J. Dodson, G. G. Dodson, D. M. Hodgkin, R. E. Hubbard, N. W. Isaacs, C. D. Reynolds, and a. l. et.: The structure of 2Zn pig insulin crystals at 1.5 Å resolution .
Philos Trans R Soc Lond B Biol Sci, 319(1195):369-456, Jul 1988.
Medline link.
S. P. Wood, G. Oliva, B. P. O'Hara, H. E. White, T. L. Blundell, S. J. Perkins, I. Sardharwalla, and M. B. Pepys.: A pentameric form of human serum amyloid P component. Crystallization, X-ray diffraction and neutron scattering studies .
J. Mol. Biol., 202(1):169-173, Jul 1988.
Medline link.
T. Blundell, D. Carney, S. Gardner, F. Hayes, B. Howlin, T. Hubbard, J. Overington, D. A. Singh, B. L. Sibanda, and M. Sutcliffe.: 18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design .
Eur. J. Biochem., 172(3):513-520, Mar 1988.
Medline link.
C. Slingsby, H. P. Driessen, D. Mahadevan, B. Bax, and T. L. Blundell.: Evolutionary and functional relationships between the basic and acidic -crystallins .
Exp Eye Res, 46(3):375-403, Mar 1988.
Medline link.
Y. V. Sergeev, Y. N. Chirgadze, S. E. Mylvaganam, H. Driessen, C. Slingsby, and T. L. Blundell.: Surface interactions of -crystallins in the crystal medium in relation to their association in the eye lens .
Proteins: Struct. Funct. Genet., 4(2):137-147, 1988.
Medline link.
M. Bajaj, M. D. Waterfield, J. Schlessinger, W. R. Taylor, and T. Blundell.: On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors .
Biochim. Biophys. Akta, 916(2):220-226, Nov 1987.
Medline link.
S. V. Luchin, R. D. Zinovieva, S. I. Tomarev, S. M. Dolgilevich, G. G. Gause, Jr, B. Bax, H. Driessen, and T. L. Blundell.: Frog lens A1-crystallin: the nucleotide sequence of the cloned cDNA and computer graphics modelling of the three-dimensional structure .
Biochim. Biophys. Akta, 916(2):163-171, Nov 1987.
Medline link.
J. Cooper, S. Foundling, A. Hemmings, T. Blundell, D. M. Jones, A. Hallett, and M. Szelke.: The structure of a synthetic pepsin inhibitor complexed with endothiapepsin .
Eur. J. Biochem., 169(1):215-221, Nov 1987.
Medline link.
M. G. Safro, N. S. Andreeva, and T. L. Blundell.: [The role of peripheral interactions in chymosin specificity] .
Mol Biol (Mosk), 21(6):1582-1589, NovDec 1987.
Medline link.
M. J. Sutcliffe, F. R. Hayes, and T. L. Blundell.: Knowledge based modelling of homologous proteins, Part II: Rules for the conformations of substituted sidechains .
Prot. Engng, 1(5):385-392, OctNov 1987.
Medline link.
M. J. Sutcliffe, I. Haneef, D. Carney, and T. L. Blundell.: Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures .
Prot. Engng, 1(5):377-384, OctNov 1987.
Medline link.
T. L. Blundell, J. Cooper, S. I. Foundling, D. M. Jones, B. Atrash, and M. Szelke.: On the rational design of renin inhibitors: X-ray studies of aspartic proteinases complexed with transition-state analogues .
Biochemistry, 26(18):5585-5590, Sep 1987.
Medline link.
J. B. Cooper, S. I. Foundling, A. Hemmings, F. E. Watson, B. L. Sibanda, T. L. Blundell, D. M. Jones, A. Hallett, B. Atrash, and M. Szelke.: Inhibitors of aspartic proteinases and their relevance to the design of antihypertensive agents .
Biochem. Soc. Trans., 15(4):751-754, Aug 1987.
Medline link.
H. Jhoti, A. N. McLeod, T. L. Blundell, H. Ishizaki, H. Nagasawa, and A. Suzuki.: Prothoracicotrophic hormone has an insulin-like tertiary structure .
FEBS Lett., 219(2):419-425, Jul 1987.
Medline link.
T. J. Hubbard and T. L. Blundell.: Comparison of solvent-inaccessible cores of homologous proteins: definitions useful for protein modelling .
Prot. Engng, 1(3):159-171, Jun 1987.
Medline link.
S. I. Foundling, J. Cooper, F. E. Watson, A. Cleasby, L. H. Pearl, B. L. Sibanda, A. Hemmings, S. P. Wood, T. L. Blundell, M. J. Valler, and a. l. et.: High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes .
Nature, 327(6120):349-352, MayJun 1987.
Medline link.
I. u. V. Sergeev, I. u. N. Chirgadze, H. Driessen, C. Slingsby, and T. L. Blundell.: [The key role of the residue 103 in the surface interactions of -crystallins] .
Mol Biol (Mosk), 21(2):377-381, MarApr 1987.
Medline link.
T. L. Blundell, B. L. Sibanda, M. J. Sternberg, and J. M. Thornton.: Knowledge-based prediction of protein structures and the design of novel molecules .
Nature, 326(6111):347-352, MarApr 1987.
Medline link.
S. I. Foundling, J. Cooper, F. E. Watson, L. H. Pearl, A. Hemmings, S. P. Wood, T. Blundell, A. Hallett, D. M. Jones, J. Sueiras, and a. l. et.: Crystallographic studies of reduced bond inhibitors complexed with an aspartic proteinase .
J Cardiovasc Pharmacol, 10 Suppl 7(6111):S59-S68, 1987.
Medline link.
L. J. Summers, T. L. Blundell, G. G. Gause, and S. I. Tomarev.: A computer graphics model of frog -crystallin based on the three-dimensional structure of calf -II crystallin .
FEBS Lett., 208(1):11-16, Nov 1986.
Medline link.
M. Bajaj, T. L. Blundell, R. Horuk, J. E. Pitts, S. P. Wood, L. K. Gowan, C. Schwabe, A. Wollmer, J. Gliemann, and S. Gammeltoft.: Coypu insulin. Primary structure, conformation and biological properties of a hystricomorph rodent insulin .
Biochem. J., 238(2):345-351, Sep 1986.
Medline link.
L. J. Summers, C. Slingsby, T. L. Blundell, J. T. den Dunnen, R. J. Moormann, and J. G. Schoenmakers.: Structural variation in mammalian -crystallins based on computer graphics analyses of human, rat and calf sequences. 1. Core packing and surface properties .
Exp Eye Res, 43(1):77-92, Jul 1986.
Medline link.
S. P. Wood, I. J. Tickle, A. M. Treharne, J. E. Pitts, Y. Mascarenhas, J. Y. Li, J. Husain, S. Cooper, T. L. Blundell, V. J. Hruby, and a. l. et.: Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding .
Science, 232(4750):633-636, May 1986.
Medline link.
J. F. Griffin, D. A. Langs, G. D. Smith, T. L. Blundell, I. J. Tickle, and S. Bedarkar.: The crystal structures of [Met5]enkephalin and a third form of [Leu5]enkephalin: observations of a novel pleated -sheet .
Proc. Nat. Acad. Sci. USA, 83(10):3272-3276, May 1986.
Medline link.
A. M. Hemmings, S. I. Foundling, B. L. Sibanda, S. P. Wood, L. H. Pearl, and T. Blundell.: Energy calculations on aspartic proteinases: human renin, endothiapepsin and its complex with an angiotensinogen fragment analogue, H-142 .
Biochem. Soc. Trans., 13(6):1036-1041, Dec 1985.
Medline link.
G. Wistow, L. Summers, and T. Blundell.: Myxococcus xanthus spore coat protein S may have a similar structure to vertebrate lens -crystallins .
Nature, 315(6022):771-773, JunJul 1985.
Medline link.
E. Dafgard, M. Bajaj, A. M. Honegger, J. Pitts, S. Wood, and T. Blundell.: The conformation of insulin-like growth factors: relationships with insulins .
J Cell Sci Suppl, 3(6022):53-64, 1985.
Medline link.
I. D. Glover, D. S. Moss, I. J. Tickle, J. E. Pitts, I. Haneef, S. P. Wood, and T. L. Blundell.: Anisotropic thermal motion and polypeptide secondary structure studied by X-ray analysis at 0.98Å resolution .
Adv Biophys, 20(6022):1-12, 1985.
Medline link.
A. Aulabaugh, W. P. Niemczura, T. L. Blundell, and W. A. Gibbons.: A study of the interactions between residues in the C- terminal half of calmodulin by one and two-dimensional NMR methods and computer modelling .
Eur. J. Biochem., 143(2):409-418, Sep 1984.
Medline link.
B. L. Sibanda, T. Blundell, P. M. Hobart, M. Fogliano, J. S. Bindra, B. W. Dominy, and J. M. Chirgwin.: Computer graphics modelling of human renin. Specificity, catalytic activity and intron-exon junctions .
FEBS Lett., 174(1):102-111, Aug 1984.
Medline link.
L. Pearl and T. Blundell.: The active site of aspartic proteinases .
FEBS Lett., 174(1):96-9101, Aug 1984.
Medline link.
P. Travers, T. L. Blundell, M. J. Sternberg, and W. F. Bodmer.: Structural and evolutionary analysis of HLA-D-region products .
Nature, 310(5974):235-238, Jul 1984.
Medline link.
I. D. Glover, D. J. Barlow, J. E. Pitts, S. P. Wood, I. J. Tickle, T. L. Blundell, K. Tatemoto, J. R. Kimmel, A. Wollmer, W. Strassburger, and a. l. et.: Conformational studies on the pancreatic polypeptide hormone family .
Eur. J. Biochem., 142(2):379-385, Jul 1984.
Medline link.
L. Summers, C. Slingsby, H. White, M. Narebor, D. Moss, L. Miller, D. Mahadevan, P. Lindley, H. Driessen, T. Blundell, and a. l. et.: The molecular structures and interactions of bovine and human -crystallins .
Ciba Found Symp, 106(2):219-236, 1984.
Medline link.
M. Bajaj, T. Blundell, and S. Wood.: Evolution in the insulin family: molecular clocks that tell the wrong time .
Biochem Soc Symp, 49(2):45-54, 1984.
Medline link.
M. Bajaj and T. Blundell.: Evolution and the tertiary structure of proteins .
Annu. Rev. Biophys. Bioeng., 13(2):453-492, 1984.
Medline link.
S. A. Chawdhury, E. J. Dodson, G. G. Dodson, C. D. Reynolds, S. P. Tolley, T. L. Blundell, A. Cleasby, J. E. Pitts, I. J. Tickle, and S. P. Wood.: The crystal structures of three non-pancreatic human insulins .
Diabetologia, 25(6):460-464, Dec 1983.
Medline link.
T. Blundell, D. Barlow, N. Borkakoti, and J. Thornton.: Solvent-induced distortions and the curvature of - helices .
Nature, 306(5940):281-283, Nov 1983.
Medline link.
G. Wistow, B. Turnell, L. Summers, C. Slingsby, D. Moss, L. Miller, P. Lindley, and T. Blundell.: X-ray analysis of the eye lens protein -II crystallin at 1.9 Å resolution .
J. Mol. Biol., 170(1):175-202, Oct 1983.
Medline link.
M. Bajaj, T. L. Blundell, J. E. Pitts, S. P. Wood, M. A. Tatnell, S. Falkmer, S. O. Emdin, L. K. Gowan, H. Crow, C. Schwabe, and a. l. et.: Dogfish insulin. Primary structure, conformation and biological properties of an elasmobranchial insulin .
Eur. J. Biochem., 135(3):535-542, Oct 1983.
Medline link.
T. Blundell, B. L. Sibanda, and L. Pearl.: Three-dimensional structure, specificity and catalytic mechanism of renin .
Nature, 304(5923):273-275, Jul 1983.
Medline link.
W. Strassburger, A. Wollmer, J. E. Pitts, I. D. Glover, I. J. Tickle, T. L. Blundell, G. J. Steffens, W. A. Gunzler, F. Otting, and L. Flohe.: Adaptation of plasminogen activator sequences to known protease structures .
FEBS Lett., 157(2):219-223, Jul 1983.
Medline link.
T. L. Blundell, S. Bedarkar, and R. E. Humbel.: Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors .
Fed Proc, 42(9):2592-2597, Jun 1983.
Medline link.
G. Inana, J. Piatigorsky, B. Norman, C. Slingsby, and T. Blundell.: Gene and protein structure of a -crystallin polypeptide in murine lens: relationship of exons and structural motifs .
Nature, 302(5906):310-315, Mar 1983.
Medline link.
I. Glover, I. Haneef, J. Pitts, S. Wood, D. Moss, I. Tickle, and T. Blundell.: Conformational flexibility in a small globular hormone: x- ray analysis of avian pancreatic polypeptide at 0.98-Å resolution .
Biopolymers, 22(1):293-304, Jan 1983.
Medline link.
W. Strassburger, U. Glatter, A. Wollmer, J. Fleischhauer, D. A. Mercola, T. L. Blundell, I. Glover, J. E. Pitts, I. J. Tickle, and S. P. Wood.: Calculated tyrosyl circular dichroism of proteins: absence of tryptophan and cystine interferences in avian pancreatic polypeptide .
FEBS Lett., 139(2):295-299, Mar 1982.
Medline link.
S. Bedarkar, T. Blundell, L. K. Gowan, J. K. McDonald, and C. Schwabe.: On the three-dimensional structure of relaxin .
Ann N Y Acad Sci, 380(2):22-33, 1982.
Medline link.
J. Gunning, S. Bedarkar, G. L. Taylor, J. M. Goodfellow, T. L. Blundell, A. Wlodawer, K. O. Hodgson, E. M. Shooter, R. Fourme, B. Gaber, and R. Williams.: Conformational studies of polypeptide growth factors: IGF and NGF .
Prog Clin Biol Res, 102 pt A(2):221-230, 1982.
Medline link.
T. L. Blundell, J. E. Pitts, and S. P. Wood.: The conformation and molecular biology of pancreatic hormones and homologous growth factors .
CRC Crit Rev Biochem, 13(2):141-213, 1982.
Medline link.
T. Blundell and S. Wood.: The conformation, flexibility, and dynamics of polypeptide hormones .
Annu. Rev. Biochem., 51(2):123-154, 1982.
Medline link.
G. Wistow, C. Slingsby, T. Blundell, H. Driessen, W. De Jong, and H. Bloemendal.: Eye-lens proteins: the three-dimensional structure of -crystallin predicted from monomeric - crystallin .
FEBS Lett., 133(1):9-16, Oct 1981.
Medline link.
L. K. Gowan, J. W. Reinig, C. Schwabe, S. Bedarkar, and T. L. Blundell.: On the primary and tertiary structure of relaxin from the sand tiger shark (Odontaspis taurus) .
FEBS Lett., 129(1):80-82, Jun 1981.
Medline link.
T. Blundell and R. Horuk.: A monomeric insulin from the casiragua: molecular model building using computer graphics .
Hoppe Seylers Z Physiol Chem, 362(6):727-733, Jun 1981.
Medline link.
T. Blundell, P. Lindley, L. Miller, D. Moss, C. Slingsby, I. Tickle, B. Turnell, and G. Wistow.: The molecular structure and stability of the eye lens: x-ray analysis of -crystallin II .
Nature, 289(5800):771-777, Feb 1981.
Medline link.
T. L. Blundell, J. E. Pitts, I. J. Tickle, and S. P. Wood.: The conformation and receptor binding of pancreatic hormones .
Biochem. Soc. Trans., 9(1):31-32, Feb 1981.
Medline link.
J. E. Pitts, S. P. Wood, L. Hearn, I. J. Tickle, C. W. Wu, T. L. Blundell, and I. C. Robinson.: Crystallisation and preliminary crystallographic data of a porcine neurophysin I-Tyr-Phe-NH2 complex .
FEBS Lett., 121(1):41-43, Nov 1980.
Medline link.
T. L. Blundell and R. E. Humbel.: Hormone families: pancreatic hormones and homologous growth factors .
Nature, 287(5785):781-787, Oct 1980.
Medline link.
E. Narebor, C. Slingsby, P. F. Lindley, and T. L. Blundell.: Preliminary x-ray crystallographic study of the turkey lens protein, -crystallin .
J. Mol. Biol., 143(2):223-225, Oct 1980.
Medline link.
R. Horuk, T. L. Blundell, N. R. Lazarus, R. W. Neville, D. Stone, and A. Wollmer.: A monomeric insulin from the porcupine (Hystrix cristata), an Old World hystricomorph .
Nature, 286(5775):822-824, Aug 1980.
Medline link.
T. Blundell.: Chemistry, structure and function of insulin and related hormones. A report on the 2nd International Insulin Symposium, Aachen, Germany, 4-7 September 1979 .
FEBS Lett., 109(2):167-170, Jan 1980.
Medline link.
T. L. Blundell, B. T. Sewell, and A. D. McLachlan.: Four-fold structural repeat in the acid proteases .
Biochim. Biophys. Akta, 580(1):24-31, Sep 1979.
Medline link.
T. L. Blundell, L. Hearn, I. J. Tickle, R. A. Palmer, B. A. Morgan, G. D. Smith, and J. F. Griffin.: Crystal structure of [Leu5]enkephalin .
Science, 205(4402):220, Jul 1979.
Medline link.
J. Tang, M. N. James, I. N. Hsu, J. A. Jenkins, and T. L. Blundell.: Structural evidence for gene duplication in the evolution of the acid proteases .
Nature, 271(5646):618-621, Feb 1978.
Medline link.
S. P. Wood, I. J. Tickle, T. L. Blundell, A. Wollmer, and D. F. Steiner.: Insulin polymorphism: some physical and biological properties of rat insulins .
Arch Biochem Biophys, 186(1):175-183, Feb 1978.
Medline link.
T. L. Blundell, S. Bedarkar, E. Rinderknecht, and R. E. Humbel.: Insulin-like growth factor: a model for tertiary structure accounting for immunoreactivity and receptor binding .
Proc. Nat. Acad. Sci. USA, 75(1):180-184, Jan 1978.
Medline link.
S. Bedarkar, W. G. Turnell, T. L. Blundell, and C. Schwabe.: Relaxin has conformational homology with insulin .
Nature, 270(5636):449-451, Dec 1977.
Medline link.
S. P. Wood, J. E. Pitts, T. L. Blundell, I. J. Tickle, and J. A. Jenkins.: Purification, crystallisation and preliminary X-ray studies on avian pancreatic polypeptide .
Eur. J. Biochem., 78(1):119-126, Aug 1977.
Medline link.
E. Subramanian, I. D. Swan, M. Liu, D. R. Davies, J. A. Jenkins, I. J. Tickle, and T. L. Blundell.: Homology among acid proteases: comparison of crystal structures at 3Å resolution of acid proteases from Rhizopus chinensis and Endothia parasitica .
Proc. Nat. Acad. Sci. USA, 74(2):556-559, Feb 1977.
Medline link.
J. A. Jenkins, I. J. Tickle, T. Sewell, and T. L. Blundell.: The structure at 0.3nm (3A) resolution of the acid proteinase from Endothia parasitica [proceedings] .
Biochem. Soc. Trans., 5(4):1120-1121, 1977.
Medline link.
J. E. Pitts, J. A. Jenkins, I. J. Tickle, T. L. Blundell, and S. P. Wood.: Structural studies on avian pancreatic polypeptide [proceedings] .
Biochem. Soc. Trans., 5(4):1119-1120, 1977.
Medline link.
J. Jenkins, I. Tickle, T. Sewell, L. Ungaretti, A. Wollmer, and T. Blundell.: X-ray analysis and circular dichroism of the acid protease from Endothia parasitica and chymosin .
Adv Exp Med Biol, 95(4):43-60, 1977.
Medline link.
S. Bedarkar, T. L. Blundell, S. Dockerill, I. J. Tickle, and S. P. Wood.: Polypeptide hormone-receptor interactions: the structure and receptor binding of insulin and glucagon .
Ciba Found Symp, 95(60):105-121, 1977.
Medline link.
S. Dockerill, T. L. Blundell, K. Sasaki, I. J. Tickle, and S. P. Wood.: The relation of structure to storage and receptor binding of glucagon [proceedings] .
Biochem. Soc. Trans., 5(4):1121-1122, 1977.
Medline link.
C. R. Beddell, G. C. Sheppey, T. L. Blundell, K. Sasaki, S. Dockerill, and P. J. Goodford.: Symmetrical features in polypeptide hormone-receptor interactions .
Int J Pept Protein Res, 9(3):161-165, 1977.
Medline link.
T. L. Blundell, S. Dockerill, K. Sasaki, I. J. Tickle, and S. P. Wood.: The relation of structure to storage and receptor binding of glucagon .
Metabolism, 25(11 Suppl 1):1331-1336, Nov 1976.
Medline link.
R. A. Pullen, D. G. Lindsay, S. P. Wood, I. J. Tickle, T. L. Blundell, A. Wollmer, G. Krail, D. Brandenburg, H. Zahn, J. Gliemann, and S. Gammeltoft.: Receptor-binding region of insulin .
Nature, 259(5542):369-373, Feb 1976.
Medline link.
J. A. Jenkins, T. L. Blundell, I. J. Tickle, and L. Ungaretti.: The low resolution structure analysis of an acid proteinase from Endothia parasitica .
J. Mol. Biol., 99(4):583-590, Dec 1975.
Medline link.
K. Sasaki, S. Dockerill, D. A. Adamiak, I. J. Tickle, and T. Blundell.: X-ray analysis of glucagon and its relationship to receptor binding .
Nature, 257(5529):751-757, Oct 1975.
Medline link.
T. L. Blundell, M. Brunori, B. Curti, B. Martino, A. Coda, M. Fumagalli, and L. Ungaretti.: Crystallization and preliminary x-ray diffraction studies on met-myoglobin from Aplysia limacina .
J. Mol. Biol., 97(4):665-666, Oct 1975.
Medline link.
T. L. Blundell and S. P. Wood.: Is the evolution of insulin Darwinian or due to selectively neutral mutation? .
Nature, 257(5523):197-203, Sep 1975.
Medline link.
R. A. Pullen, J. A. Jenkins, I. J. Tickle, S. P. Wood, and T. L. Blundell.: The relation of polypeptide hormone structure and flexibility to receptor binding: the relevance of X-ray studies on insulins, glucagon and human placental lactogen .
Mol Cell Biochem, 8(1):5-20, Jul 1975.
Medline link.
S. P. Wood, T. L. Blundell, A. Wollmer, N. R. Lazarus, and R. W. Neville.: The relation of conformation and association of insulin to receptor binding; x-ray and circular-dichroism studies on bovine and hystricomorph insulins .
Eur. J. Biochem., 55(3):531-542, Jul 1975.
Medline link.
T. L. Blundell, J. F. Cutfield, S. M. Cutfield, E. J. Dodson, G. G. Dodson, D. C. Hodgkin, and D. A. Mercola.: Three-dimensional atomic structure of insulin and its relationship to activity .
Diabetes, 21(2):Suppl2:492+, 1972.
Medline link.
T. L. Blundell, J. F. Cutfield, E. J. Dodson, G. G. Dodson, D. C. Hodgkin, and D. A. Mercola.: The crystal structure of rhombohedral 2 zinc insulin .
Cold Spring Harb Symp Quant Biol, 36(2):233-241, 1972.
Medline link.
T. L. Blundell, J. F. Cutfield, G. G. Dodson, E. Dodson, D. C. Hodgkin, and D. Mercola.: The structure and biology of insulin .
Biochem. J., 125(3):50P-51P, Dec 1971.
Medline link.
T. L. Blundell, J. F. Cutfield, S. M. Cutfield, E. J. Dodson, G. G. Dodson, D. C. Hodgkin, D. A. Mercola, and M. Vijayan.: Atomic positions in rhombohedral 2-zinc insulin crystals .
Nature, 231(5304):506-511, Jun 1971.
Medline link.
T. L. Blundell, G. G. Dodson, E. Dodson, D. C. Hodgkin, and M. Vijayan.: X-ray analysis and the structure of insulin .
Recent Prog Horm Res, 27(5304):1-40, 1971.
Medline link.

University of Cambridge, Department of Biochemistry

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